TP2
TP2 structure
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Common Name | TP2 | ||
|---|---|---|---|---|
| CAS Number | 420089-51-6 | Molecular Weight | 419.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H14F5NO3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of TP2Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity[1]. |
| Name | Thiophene-2 |
|---|---|
| Synonym | More Synonyms |
| Description | Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity[1]. |
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| Related Catalog | |
| Target |
MIC: 1 μM (Mycobacterium tuberculosis) |
| In Vitro | In vitro, TP inhibits fatty acyl-AMP loading onto Pks13. Thiophene-2 (TP2; 0-125 μM) inhibits loading of wild-type Mycobacterium tuberculosis (Mtb) Pks13 (Pks13_WT) in a dose-dependent manner. Thiophene-2 also inhibits palmitic acid (FL C16) loading onto the TP-resistant F79S mutant protein[1]. Thiophene-2 has an IC50 versus monkey kidney Vero cells and human liver carcinoma HepG2 cells of 17.5 and 7.30 μM, respectively. Significant intracellular killing activity within BCG-infected J774A.1 macrophage cells is observed at Thiophene-2 concentrations of 12.8 μM[1]. |
| References |
| Molecular Formula | C18H14F5NO3S |
|---|---|
| Molecular Weight | 419.37 |
| InChIKey | AVRWEULSKHQETA-UHFFFAOYSA-N |
| SMILES | COC(=O)c1c(NC(=O)c2c(F)c(F)c(F)c(F)c2F)sc2c1CCCCC2 |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
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| MFCD01337175 |