Trilobatin
Trilobatin structure
|
Common Name | Trilobatin | ||
|---|---|---|---|---|
| CAS Number | 4192-90-9 | Molecular Weight | 436.409 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 787.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H24O10 | Melting Point | 163 °C | |
| MSDS | N/A | Flash Point | 277.1±26.4 °C | |
Use of TrilobatinTrilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3]. |
| Name | 1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one |
|---|---|
| Synonym | More Synonyms |
| Description | Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3]. |
|---|---|
| Related Catalog | |
| Target |
HIV-1 SGLT1/2 |
| In Vitro | Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 787.9±60.0 °C at 760 mmHg |
| Melting Point | 163 °C |
| Molecular Formula | C21H24O10 |
| Molecular Weight | 436.409 |
| Flash Point | 277.1±26.4 °C |
| Exact Mass | 436.136932 |
| PSA | 177.14000 |
| LogP | 1.43 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.686 |
|
~49%
Trilobatin CAS#:4192-90-9 |
| Literature: Gupte, Amol; Buolamwini, John K. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 917 - 921 |
|
~%
Trilobatin CAS#:4192-90-9 |
| Literature: Jorio Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1929,1936 |
|
~%
Trilobatin CAS#:4192-90-9 |
| Literature: Jorio Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1929,1936 |
|
~%
Trilobatin CAS#:4192-90-9 |
| Literature: Jorio Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 1929,1936 |
CAS#:60-82-2| UNII:23298I791N |
| 1-Propanone, 1-[4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)- |
| 3,5-Dihydroxy-4-[3-(4-hydroxyphenyl)propanoyl]phenyl β-D-glucopyranoside |
| p-Phloridzin |
| phloretin-4-D-glucoside |
| T6OTJ BOR CQ EQ DV2R DQ&& CQ DQ EQ F1Q &&β-D-Gluco Form |
| p-Phlorizin |
| 1-Propanone, 1-(4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)- |
| Trilobatin |
| 1-(4-(β-D-Glucopyranosyloxy)-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone |
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