Rilapladib

Modify Date: 2025-08-25 20:37:43

Rilapladib Structure
Rilapladib structure
 Common Name Rilapladib
CAS Number 412950-08-4 Molecular Weight 735.80500
Density 1.36g/cm3 Boiling Point N/A
Molecular Formula C40H38F5N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Rilapladib


Rilapladib is a selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) inhibitor with an IC50 of 230 pM.

 Names

Name 2-[2-[(2,3-difluorophenyl)methylsulfanyl]-4-oxoquinolin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide
Synonym More Synonyms

 Rilapladib Biological Activity

Description Rilapladib is a selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) inhibitor with an IC50 of 230 pM.
Related Catalog
Target

IC50: 230 pM (Lp-PLA2)[1].

References

[1]. Shaddinger BC, et al. Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials. PLoS One. 2014 Jan 27;9(1):e83094.

 Chemical & Physical Properties

Density 1.36g/cm3
Molecular Formula C40H38F5N3O3S
Molecular Weight 735.80500
Exact Mass 735.25500
PSA 80.08000
LogP 8.33530
Storage condition 2-8℃

 Synthetic Route

[2-(2,3-difluorobenzylthio)-4-oxo-4H-quinolin-1-yl]acetic acid structure

[2-(2,3-difluor...

CAS#:412950-86-8

S-isopentyl N-phenylthiocarbamate structure

S-isopentyl N-p...

CAS#:412950-89-1

~82%

Rilapladib Structure

Rilapladib

CAS#:412950-08-4

Literature: GLAXO GROUP LIMITED; LEE, Mei-yin Patent: WO2013/30374 A1, 2013 ; Location in patent: Page/Page column 22; 23 ;

 Synonyms

MTdU
Rilapladib
UNII-O14CWE893Z
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Related Compounds: More...
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1396873-03-2
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Chemsrc provides Rilapladib(CAS#:412950-08-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Rilapladib are included as well.>> amp version: Rilapladib

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