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Rilapladib

Names

[ CAS No. ]:
412950-08-4

[ Name ]:
Rilapladib

[Synonym ]:
MTdU
Rilapladib
UNII-O14CWE893Z

Biological Activity

[Description]:

Rilapladib is a selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) inhibitor with an IC50 of 230 pM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Neurological Disease

[Target]

IC50: 230 pM (Lp-PLA2)[1].


[References]

[1]. Shaddinger BC, et al. Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials. PLoS One. 2014 Jan 27;9(1):e83094.


[Related Small Molecules]

SHP099 hydrochloride | LB-100 | Salubrinal | Calyculin A | SF1670 | Stibogluconate sodium | TPI-1 | MSI-1436 lactate | Microcystin-LR | Sodium orthovanadate | GSK 2830371 | PTP1B-IN-2 | Rosiptor | NSC 663284(DA3003-1) | TCS 401

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Molecular Formula ]:
C40H38F5N3O3S

[ Molecular Weight ]:
735.80500

[ Exact Mass ]:
735.25500

[ PSA ]:
80.08000

[ LogP ]:
8.33530

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds

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