Firategrast

Modify Date: 2024-01-14 17:16:06

Firategrast Structure
Firategrast structure
Common Name Firategrast
CAS Number 402567-16-2 Molecular Weight 499.50300
Density N/A Boiling Point N/A
Molecular Formula C27H27F2NO6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Firategrast


Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist.

 Names

Name (2S)-2-[(2,6-difluorobenzoyl)amino]-3-[4-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]phenyl]propanoic acid
Synonym More Synonyms

 Firategrast Biological Activity

Description Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist.
Related Catalog
Target

α4β1/α4β7[1]

In Vitro Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS)[1].
References

[1]. Grove RA, et al. Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis. Eur J Neurol. 2013 Jul;20(7):1032-42.

 Chemical & Physical Properties

Molecular Formula C27H27F2NO6
Molecular Weight 499.50300
Exact Mass 499.18100
PSA 97.58000
LogP 5.18600
Storage condition 2-8℃

 Synonyms

Firategrast (USAN)
Firategrast
UNII-OJY3SK9H5F
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