402567-16-2

402567-16-2 structure

Name: Firategrast
Chemical Name: (2S)-2-[(2,6-difluorobenzoyl)amino]-3-[4-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]phenyl]propanoic acid
CAS Number: 402567-16-2
Molecular Formula: C₂₇H₂₇F₂NO₆
Molecular Weight: 499.50300
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2017-06-28 00:58:29
Modify Date: 2025-09-21 07:19:26
Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist.

Name	(2S)-2-[(2,6-difluorobenzoyl)amino]-3-[4-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]phenyl]propanoic acid
Synonyms	Firategrast (USAN) Firategrast UNII-OJY3SK9H5F

Description	Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Integrin Research Areas >> Neurological Disease
Target	α4β1/α4β7[1]
In Vitro	Firategrast is an orally bioavailable α4β1/α4β7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS)[1].
References	[1]. Grove RA, et al. Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis. Eur J Neurol. 2013 Jul;20(7):1032-42.