Ophiopogonin B

Modify Date: 2024-01-05 13:17:40

Ophiopogonin B structure	Common Name	Ophiopogonin B
	CAS Number	38971-41-4	Molecular Weight	722.902
	Density	1.3±0.1 g/cm3	Boiling Point	835.7±65.0 °C at 760 mmHg
	Molecular Formula	C₃₉H₆₂O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	459.2±34.3 °C

Use of Ophiopogonin B

Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1].

Name	ophiopogonin B
Synonym	More Synonyms

Description	Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> JNK
Target	JNK
In Vitro	Ophiopogonin B (0, 5, 10and 20 μM) suppresses the proliferation of HT-29 and HCT-116 cell lines through the G0/G1 phase cell cycle arrest[1]. Ophiopogonin B induces apoptosis by inhibiting the expression of Bax and cleaved caspase 3 and promoting the expression of Bcl-2. Treatment with Ophiopogonin B also increases the expression of Beclin 1 and the conversion of LC3I to LC3II with the activation of JNK/c-Jun signaling pathway[1].
References	[1]. Gao GY, et al. Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Biomed Pharmacother. 2018 Dec;108:1208-1215.

Density	1.3±0.1 g/cm3
Boiling Point	835.7±65.0 °C at 760 mmHg
Molecular Formula	C₃₉H₆₂O₁₂
Molecular Weight	722.902
Flash Point	459.2±34.3 °C
Exact Mass	722.424133
PSA	176.76000
LogP	5.63
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.604

Hazard Codes	Xi

Glycoside O-4 structure

Glycoside O-4

CAS#:94898-61-0

~%

Ophiopogonin B Structure

Ophiopogonin B

CAS#:38971-41-4

Literature: Watanabe, Yoshiaki; Sanada, Shuichi; Ida, Yoshiteru; Shoji, Junzo Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3994 - 4002

N/A structure

N/A

CAS#:94901-57-2

~%

Ophiopogonin B Structure

Ophiopogonin B

CAS#:38971-41-4

Literature: Watanabe, Yoshiaki; Sanada, Shuichi; Ida, Yoshiteru; Shoji, Junzo Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3994 - 4002

Precursor 1
CAS#:94898-61-0 Glycoside O-4
DownStream 1
CAS#:472-11-7 Ruscogenin

α-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-

4-Octacosanone,24-hydroxy

24-hydroxy-4-octacosanone

(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-α-D-galactopyranoside

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ophiopogonin B
Price: ￥3528.0/5mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ophiopogonin B
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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