methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate

Modify Date: 2025-09-18 20:01:48

methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate structure	Common Name	methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate
	CAS Number	386704-15-0	Molecular Weight	247.17100
	Density	1.341g/cm3	Boiling Point	295.5ºC at 760 mmHg
	Molecular Formula	C₁₀H₈F₃NO₃	Melting Point	60-62ºC
	MSDS	N/A	Flash Point	132.5ºC

Use of methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate

11β-HSD1-IN-8 (compound c6a) is a 11β‑HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β‑HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline[1].

Name	methyl 3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propanoate
Synonym	More Synonyms

Description	11β-HSD1-IN-8 (compound c6a) is a 11β‑HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β‑HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	IC50: 2.3 μM (human 11β‑HSD)[1]
In Vitro	11β-HSD1-IN-8 (0-50 μM) inhibits human and rat 11β‑HSD1 with IC50 values of 2.3 μM and ＞50 μM, respectively[1].

Density	1.341g/cm3
Boiling Point	295.5ºC at 760 mmHg
Melting Point	60-62ºC
Molecular Formula	C₁₀H₈F₃NO₃
Molecular Weight	247.17100
Flash Point	132.5ºC
Exact Mass	247.04600
PSA	56.26000
LogP	1.84620
Index of Refraction	1.459
InChIKey	YXRIRKKHNGRGRZ-UHFFFAOYSA-N
SMILES	COC(=O)CC(=O)c1ccc(C(F)(F)F)nc1

Hazard Codes	Xi
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

MFCD01862654

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