(+)-Penbutolol

Modify Date: 2024-01-17 19:01:15

(+)-Penbutolol structure	Common Name	(+)-Penbutolol
	CAS Number	38363-41-6	Molecular Weight	291.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₉NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (+)-Penbutolol

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].

Name	(+)-Penbutolol

Description	(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	IC50: 0.74 μM (β-adrenoceptor)[1].
In Vitro	(+)-penbutolol on the [Ca2+]i-increase induced by LPC is concentration-dependent[1]. (+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10-6 M, 5×10-6 M and 10-5 M, respectively)[2].
References	[1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70. [2]. Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8.

Molecular Formula	C₁₈H₂₉NO₂
Molecular Weight	291.43

DC Chemicals Limited
China
Product Name: (+)-Penbutolol ((R)-Penbutolol; (+)-Isopenbutolol)
Price: $750.0/100mg $1500.0/250mg $3000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isopenbutolol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥1650/10 mM * 1 mL in DMSO

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(+)-Penbutolol

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(+)-Penbutolol Biological Activity

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