Macimorelin Acetate

Modify Date: 2024-01-02 16:44:10

Macimorelin Acetate structure	Common Name	Macimorelin Acetate
	CAS Number	381231-18-1	Molecular Weight	474.555
	Density	1.3±0.1 g/cm3	Boiling Point	948.6±65.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₃₀N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	527.5±34.3 °C

Use of Macimorelin Acetate

Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].

Name	2-amino-N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide
Synonym	More Synonyms

Description	Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> GHSR
Target	GHSR[1]
In Vivo	Macimorelin (5 mg/kg, i.p. twice daily for 2 weeks) decreases the number and duration of seizures in IHKA mouse model[2]. Animal Model: Intrahippocampal kainic acid (IHKA) mouse model[2] Dosage: 5 mg/kg Administration: Intraperitoneal injection (i.p.), twice daily for 2 weeks. Result: Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect.
References	[1]. Jose M Garcia, et al. Macimorelin as a Diagnostic Test for Adult GH Deficiency. J Clin Endocrinol Metab. 2018 Aug 1;103(8):3083-3093. [2]. An Buckinx, et al. Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy. Eur J Neurol. 2021 Sep;28(9):3100-3112. [3]. Ali SA, Garcia JM. Randomized clinical trial of the novel oral ghrelin mimetic macimorelin in the treatment of cancer cachexia: study design and preliminary results. Endocr Rev. 2013;34:

Density	1.3±0.1 g/cm3
Boiling Point	948.6±65.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₀N₆O₃
Molecular Weight	474.555
Flash Point	527.5±34.3 °C
Exact Mass	474.237946
PSA	151.88000
LogP	2.64
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.676