IBS003031
Modify Date: 2024-01-06 10:55:22
IBS003031 structure
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Common Name | IBS003031 | ||
|---|---|---|---|---|
| CAS Number | 381177-81-7 | Molecular Weight | 331.368 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 570.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H17N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 298.9±28.7 °C | |
Use of IBS003031IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays; remarkably increased the amount of unphosphorylated YAP1 and decreased that of phosphorylated YAP1, enhanced the expression of YAP1 target genes, CTGF and CYR61, in U2OS cells; does not inhibits LATS1/2 activities or blocks the interaction of YAP1 and LATS kinases; decreased the viability in the dose-dependent manner in MM cells and enhanced Bax expression, increased p73-dependent transcription MDM2, FAS, and BAX in mRNA level. |
| Name | 2-Ethoxy-6-[(Z)-(2-furylmethylene)amino]-9-acridinamine |
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| Synonym | More Synonyms |
| Description | IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays; remarkably increased the amount of unphosphorylated YAP1 and decreased that of phosphorylated YAP1, enhanced the expression of YAP1 target genes, CTGF and CYR61, in U2OS cells; does not inhibits LATS1/2 activities or blocks the interaction of YAP1 and LATS kinases; decreased the viability in the dose-dependent manner in MM cells and enhanced Bax expression, increased p73-dependent transcription MDM2, FAS, and BAX in mRNA level. |
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| References | References 1. Maruyama J, et al. Mol Cancer Res. 2018 Feb;16(2):197-211. View Related Products by Target Yes-associated Protein (YAP) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 570.6±45.0 °C at 760 mmHg |
| Molecular Formula | C20H17N3O2 |
| Molecular Weight | 331.368 |
| Flash Point | 298.9±28.7 °C |
| Exact Mass | 331.132080 |
| LogP | 2.70 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.657 |
| 2-Ethoxy-6-[(Z)-(2-furylmethylene)amino]-9-acridinamine |
| 3,9-Acridinediamine, 7-ethoxy-N3-[(1Z)-2-furanylmethylene]- |
| 7-Ethoxy-N3-[(Z)-2-furylmethylene]acridine-3,9-diamine |