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IBS003031

Names

[ CAS No. ]:
381177-81-7

[ Name ]:
IBS003031

[Synonym ]:
2-Ethoxy-6-[(Z)-(2-furylmethylene)amino]-9-acridinamine
3,9-Acridinediamine, 7-ethoxy-N3-[(1Z)-2-furanylmethylene]-
7-Ethoxy-N3-[(Z)-2-furylmethylene]acridine-3,9-diamine

Biological Activity

[Description]:

IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays; remarkably increased the amount of unphosphorylated YAP1 and decreased that of phosphorylated YAP1, enhanced the expression of YAP1 target genes, CTGF and CYR61, in U2OS cells; does not inhibits LATS1/2 activities or blocks the interaction of YAP1 and LATS kinases; decreased the viability in the dose-dependent manner in MM cells and enhanced Bax expression, increased p73-dependent transcription MDM2, FAS, and BAX in mRNA level.

[References]

References 1. Maruyama J, et al. Mol Cancer Res. 2018 Feb;16(2):197-211. View Related Products by Target Yes-associated Protein (YAP)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
570.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H17N3O2

[ Molecular Weight ]:
331.368

[ Flash Point ]:
298.9±28.7 °C

[ Exact Mass ]:
331.132080

[ LogP ]:
2.70

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.657

Related Compounds