381177-81-7

381177-81-7 structure

Name: IBS003031
Chemical Name: 2-Ethoxy-6-[(Z)-(2-furylmethylene)amino]-9-acridinamine
CAS Number: 381177-81-7
Molecular Formula: C₂₀H₁₇N₃O₂
Molecular Weight: 331.368
Create Date: 2020-01-12 17:22:50
Modify Date: 2024-01-06 10:55:22
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays; remarkably increased the amount of unphosphorylated YAP1 and decreased that of phosphorylated YAP1, enhanced the expression of YAP1 target genes, CTGF and CYR61, in U2OS cells; does not inhibits LATS1/2 activities or blocks the interaction of YAP1 and LATS kinases; decreased the viability in the dose-dependent manner in MM cells and enhanced Bax expression, increased p73-dependent transcription MDM2, FAS, and BAX in mRNA level.

Name	2-Ethoxy-6-[(Z)-(2-furylmethylene)amino]-9-acridinamine
Synonyms	2-Ethoxy-6-[(Z)-(2-furylmethylene)amino]-9-acridinamine 3,9-Acridinediamine, 7-ethoxy-N3-[(1Z)-2-furanylmethylene]- 7-Ethoxy-N3-[(Z)-2-furylmethylene]acridine-3,9-diamine

Description	IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays; remarkably increased the amount of unphosphorylated YAP1 and decreased that of phosphorylated YAP1, enhanced the expression of YAP1 target genes, CTGF and CYR61, in U2OS cells; does not inhibits LATS1/2 activities or blocks the interaction of YAP1 and LATS kinases; decreased the viability in the dose-dependent manner in MM cells and enhanced Bax expression, increased p73-dependent transcription MDM2, FAS, and BAX in mRNA level.
References	References 1. Maruyama J, et al. Mol Cancer Res. 2018 Feb;16(2):197-211. View Related Products by Target Yes-associated Protein (YAP)