ZQ 16
Modify Date: 2024-01-30 14:39:00
ZQ 16 structure
|
Common Name | ZQ 16 | ||
|---|---|---|---|---|
| CAS Number | 376616-73-8 | Molecular Weight | 228.311 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H16N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZQ 16A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM; does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120; increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM; activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction; reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM. |
| Name | ZQ-16 |
|---|---|
| Synonym | More Synonyms |
| Description | A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM; does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120; increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM; activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction; reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM. |
|---|---|
| References | References 1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44. 2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83. View Related Products by Target Free Fatty Acid Receptor (FFAR) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H16N2O2S |
| Molecular Weight | 228.311 |
| Exact Mass | 228.093246 |
| LogP | 2.68 |
| Index of Refraction | 1.588 |
| 2-(Hexylsulfanyl)-6-hydroxy-4(3H)-pyrimidinone |
| 2-(Hexylsulfanyl)-6-hydroxypyrimidin-4(3H)-one |
| ZQ-16 |
| MFCD00475645 |
| 4(3H)-Pyrimidinone, 2-(hexylthio)-6-hydroxy- |
| 2-(hexylthio)-6-hydroxy-4(3H)-pyrimidinone |