Name | ZQ-16 |
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Synonyms |
2-(Hexylsulfanyl)-6-hydroxy-4(3H)-pyrimidinone
2-(Hexylsulfanyl)-6-hydroxypyrimidin-4(3H)-one ZQ-16 MFCD00475645 4(3H)-Pyrimidinone, 2-(hexylthio)-6-hydroxy- 2-(hexylthio)-6-hydroxy-4(3H)-pyrimidinone |
Description | A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM; does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120; increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM; activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction; reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM. |
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References | References 1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44. 2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83. View Related Products by Target Free Fatty Acid Receptor (FFAR) |
Density | 1.3±0.1 g/cm3 |
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Molecular Formula | C10H16N2O2S |
Molecular Weight | 228.311 |
Exact Mass | 228.093246 |
LogP | 2.68 |
Index of Refraction | 1.588 |