ZQ 16

Names

[ Name ]:
ZQ 16

[Synonym ]:
2-(Hexylsulfanyl)-6-hydroxy-4(3H)-pyrimidinone
2-(Hexylsulfanyl)-6-hydroxypyrimidin-4(3H)-one
ZQ-16
MFCD00475645
4(3H)-Pyrimidinone, 2-(hexylthio)-6-hydroxy-
2-(hexylthio)-6-hydroxy-4(3H)-pyrimidinone

Biological Activity

[Description]:

A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM; does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120; increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM; activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction; reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM.

[References]

References 1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44. 2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83. View Related Products by Target Free Fatty Acid Receptor (FFAR)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₀H₁₆N₂O₂S

[ Molecular Weight ]:
228.311

[ Exact Mass ]:
228.093246

[ LogP ]:
2.68

[ Index of Refraction ]:
1.588

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.