bleomycin A6

Modify Date: 2025-08-27 18:53:09

bleomycin A6 structure	Common Name	bleomycin A6
	CAS Number	37293-17-7	Molecular Weight	1497.66000
	Density	1.53g/cm3	Boiling Point	N/A
	Molecular Formula	C₆₀H₉₆N₂₀O₂₁S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of bleomycin A6

Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].

Name	bleomycin A6
Synonym	More Synonyms

Description	Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Boanmycin (50-125 μg/mL, 0.5-36 h) can induce apoptosis and block the cell cycle in the G2/M phase in Eca-109 cells[2]. Boanmycin (6.7 µg/mL, 24 h) induces cell senescence[3]. Cell Viability Assay[3] Cell Line: Human lung fibroblast cell line IMR90, mouse primary osteoblasts (OBs) Concentration: 6.7 µg/mL Incubation Time: 24 hours Result: Showed a 90% positive number of SA-βgal stained cells in IMR90 cells and 95% in OBs compared to 30% in the control group. RT-PCR[3] Cell Line: Mouse primary osteoblasts (OBs) Concentration: 6.7 µg/mL Incubation Time: 24 hours Result: Increased senescence-associated secretory phenotype (SASP) factor IL-6 expression up to six-fold.
In Vivo	Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks)can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells[1]. Animal Model: BALB/c nude mice with HT-29 or Hce-8693 cells[1] Dosage: 10 or 15 mg/kg Administration: Intraperitoneal injection; twice a week; 5 weeks Result: Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model. Animal Model: BALB/c nude mice with CT-26 cells[1] Dosage: 10 mg/kg Administration: Intramuscular injection; every second day; 10 times Result: Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.
References	[1]. Y C Deng, et al. Activity of boanmycin against colorectal cancer. World J Gastroenterol. 2001 Feb;7(1):93-7. [2]. Hao Tang, et al. Effect of boanmycin on apoptosis and cell cycle of human esophageal cancer(Eca-109) cells]. Ai Zheng. 2002 Aug;21(8):855-9. [3]. Peng Chen, et al. The chemotherapeutic drug boanmycin induces cell senescence and senescence-associated secretory phenotype factors, thus acquiring the potential to remodel the tumor microenvironment. Anticancer Drugs. 2016 Feb;27(2):84-8.

Density	1.53g/cm3
Molecular Formula	C₆₀H₉₆N₂₀O₂₁S₂
Molecular Weight	1497.66000
Exact Mass	1496.65000
PSA	733.63000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EC5991325

CHEMICAL NAME :: Bleomycinamide, N(sup 1)-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-

CAS REGISTRY NUMBER :: 37293-17-7

LAST UPDATED :: 199607

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C60-H96-N20-O21-S2

MOLECULAR WEIGHT :: 1497.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80330 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 97780 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70530 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 24500 ug/kg/7W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990

Zhengguangmycin A6

Pingyangmycin A6

N1-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]bleomycinamide

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Boanmycin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Boanmycin
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: bleomycin A6
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.