3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
Modify Date: 2025-09-02 10:42:18
3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase structure
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Common Name | 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase | ||
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| CAS Number | 37277-69-3 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferaseThis enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-α-fucosylation of the GlcNAc in β-D-Gal-(1→3)-β-GlcNAc sequences (with some activity also as 3-α-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-α- and 4-α-fucosyltransferase activities. Reaction: GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-D-glucosaminyl-R = GDP + β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl-R |
| Name | 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase |
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| Synonym | More Synonyms |
| Description | This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-α-fucosylation of the GlcNAc in β-D-Gal-(1→3)-β-GlcNAc sequences (with some activity also as 3-α-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-α- and 4-α-fucosyltransferase activities. Reaction: GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-D-glucosaminyl-R = GDP + β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl-R |
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| No Any Chemical & Physical Properties |
| EC 2.4.1.65 |
| (Lea)-dependent (α-3/4)-fucosyltransferase |
| α(1,3/1,4) fucosyltransferase III |
| α-(1→4)-L-fucosyltransferase |
| α-4-L-fucosyltransferase |
| β-acetylglucosaminylsaccharide fucosyltransferase |
| FucT-II |
| Lewis α-(1→3/4)-fucosyltransferase |
| Lewis blood group α-(1→3/4)-fucosyltransferase |
| Lewis(Le) blood group gene-dependent α-(1→3/4)-L-fucosyltransferase |
| blood group Lewis α-4-fucosyltransferase |
| blood-group substance Lea-dependent fucosyltransferase |
| guanosine diphosphofucose-β-acetylglucosaminylsaccharide 4-α-L-fucosyltransferase |
| guanosine diphosphofucose-glycoprotein 4-α-L-fucosyltransferase |
| guanosine diphosphofucose-glycoprotein 4-α-fucosyltransferase |
| 3-α-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase |
| GDP-β-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase |
| GDP-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase |