37277-69-3
37277-69-3 structure
- Name: 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
- Chemical Name: 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
- CAS Number: 37277-69-3
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-04-09 15:15:54
- Modify Date: 2024-01-02 23:43:16
-
This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-α-fucosylation of the GlcNAc in β-D-Gal-(1→3)-β-GlcNAc sequences (with some activity also as 3-α-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-α- and 4-α-fucosyltransferase activities. Reaction: GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-D-glucosaminyl-R = GDP + β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl-R
| Name | 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase |
|---|---|
| Synonyms |
EC 2.4.1.65
(Lea)-dependent (α-3/4)-fucosyltransferase α(1,3/1,4) fucosyltransferase III α-(1→4)-L-fucosyltransferase α-4-L-fucosyltransferase β-acetylglucosaminylsaccharide fucosyltransferase FucT-II Lewis α-(1→3/4)-fucosyltransferase Lewis blood group α-(1→3/4)-fucosyltransferase Lewis(Le) blood group gene-dependent α-(1→3/4)-L-fucosyltransferase blood group Lewis α-4-fucosyltransferase blood-group substance Lea-dependent fucosyltransferase guanosine diphosphofucose-β-acetylglucosaminylsaccharide 4-α-L-fucosyltransferase guanosine diphosphofucose-glycoprotein 4-α-L-fucosyltransferase guanosine diphosphofucose-glycoprotein 4-α-fucosyltransferase 3-α-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase GDP-β-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase GDP-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase |
| Description | This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-α-fucosylation of the GlcNAc in β-D-Gal-(1→3)-β-GlcNAc sequences (with some activity also as 3-α-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-α- and 4-α-fucosyltransferase activities. Reaction: GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-D-glucosaminyl-R = GDP + β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl-R |
|---|
| No Any Chemical & Physical Properties |