3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase

Names

[ Name ]:
3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase

[Synonym ]:
EC 2.4.1.65
(Lea)-dependent (α-3/4)-fucosyltransferase
α(1,3/1,4) fucosyltransferase III
α-(1→4)-L-fucosyltransferase
α-4-L-fucosyltransferase
β-acetylglucosaminylsaccharide fucosyltransferase
FucT-II
Lewis α-(1→3/4)-fucosyltransferase
Lewis blood group α-(1→3/4)-fucosyltransferase
Lewis(Le) blood group gene-dependent α-(1→3/4)-L-fucosyltransferase
blood group Lewis α-4-fucosyltransferase
blood-group substance Lea-dependent fucosyltransferase
guanosine diphosphofucose-β-acetylglucosaminylsaccharide 4-α-L-fucosyltransferase
guanosine diphosphofucose-glycoprotein 4-α-L-fucosyltransferase
guanosine diphosphofucose-glycoprotein 4-α-fucosyltransferase
3-α-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
GDP-β-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase
GDP-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase

Biological Activity

[Description]:

This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-α-fucosylation of the GlcNAc in β-D-Gal-(1→3)-β-GlcNAc sequences (with some activity also as 3-α-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-α- and 4-α-fucosyltransferase activities. Reaction: GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-D-glucosaminyl-R = GDP + β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl-R

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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