Pholedrine

Modify Date: 2025-08-26 17:27:42

Pholedrine Structure
Pholedrine structure
 Common Name Pholedrine
CAS Number 370-14-9 Molecular Weight 165.23200
Density 1.014g/cm3 Boiling Point 279.4ºC at 760mmHg
Molecular Formula C10H15NO Melting Point 162-163°
MSDS Chinese USA Flash Point 109ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Pholedrine


Pholedrine is an Autonomic Agent. It is a a sympathomimetic vasoconstrictive drug.

 Names

Name rac Pholedrine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.014g/cm3
Boiling Point 279.4ºC at 760mmHg
Melting Point 162-163°
Molecular Formula C10H15NO
Molecular Weight 165.23200
Flash Point 109ºC
Exact Mass 165.11500
PSA 32.26000
LogP 1.93350
Index of Refraction 1.532
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL8400000
CHEMICAL NAME :
Phenol, p-(2-(methylamino)propyl)-
CAS REGISTRY NUMBER :
370-14-9
LAST UPDATED :
199603
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H15-N-O
MOLECULAR WEIGHT :
165.26
WISWESSER LINE NOTATION :
QR D1Y1&M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - changes in psychophysiological tests
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,442,1966
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,101,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,328,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26-36-45-36/37-16-7
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS SL8400000
HS Code 2922299090

 Synthetic Route

4-Hydroxyphenylacetone structure

4-Hydroxyphenyl...

CAS#:770-39-8

methylamine structure

methylamine

CAS#:74-89-5

~%

Pholedrine Structure

Pholedrine

CAS#:370-14-9

Literature: Knoll A.G. Patent: DE674753 , 1936 ; DRP/DRBP Org.Chem.
Hydroxyamphetamine structure

Hydroxyamphetamine

CAS#:103-86-6

~%

Pholedrine Structure

Pholedrine

CAS#:370-14-9

Literature: Knoll A.G. Patent: DE672372 , 1936 ; DRP/DRBP Org.Chem.
Formaldehyde structure

Formaldehyde

CAS#:50-00-0

Hydroxyamphetamine structure

Hydroxyamphetamine

CAS#:103-86-6

~%

Pholedrine Structure

Pholedrine

CAS#:370-14-9

Literature: Knoll A.G. Patent: DE672372 , 1936 ; DRP/DRBP Org.Chem.
DL-Methamphetamine structure

DL-Methamphetamine

CAS#:7632-10-2

~%

Pholedrine Structure

Pholedrine

CAS#:370-14-9

Benzeneethanamine, a-methyl- structure

Benzeneethanami...

CAS#:60-15-1

Literature: Blume Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 5 p. 805 - 809

 Customs

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles27

More Articles
Identification of new urinary metabolites of famprofazone in humans.

J. Anal. Toxicol. 22(1) , 55-60, (1998)

Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and ...

Urinary excretion of the main metabolites of methamphetamine, including p-hydroxymethamphetamine-sulfate and p-hydroxymethamphetamine-glucuronide, in humans and rats.

Xenobiotica 36(2-3) , 259-67, (2006)

The urinary concentrations of the main metabolites of methamphetamine (MA), specifically p-hydroxymethamphetamine-sulfate (p-OHMA-Sul) and p-hydroxymethamphetamine-glucuronide (p-OHMA-Glu), were direc...

LC-MS/MS analysis of pholedrine in a fatal intoxication case.

Forensic Sci. Int. 133(1-2) , 101-6, (2003)

Pholedrine (4'-hydroxymethamphetamine) is a cardiovascular agent exerting hypertensive and adrenergic effects. High doses may cause a drop in the peripheral circulation blood flow and increase blood p...

 Synonyms

4-[2-(methylamino)propyl]phenol
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Chemsrc provides Pholedrine(CAS#:370-14-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Pholedrine are included as well.>> amp version: Pholedrine

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