Bragsin1(Bragsin 1)

Modify Date: 2024-01-14 21:04:05

Bragsin1(Bragsin 1) Structure
Bragsin1(Bragsin 1) structure
 Common Name Bragsin1(Bragsin 1)
CAS Number 369631-68-5 Molecular Weight 273.16
Density N/A Boiling Point N/A
Molecular Formula C11H6F3NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bragsin1(Bragsin 1)


Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].

 Names

Name Bragsin1

 Bragsin1(Bragsin 1) Biological Activity

Description Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].
Related Catalog
Target

IC50: 3 μM (BRAG2)[1]

References

[1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.

 Chemical & Physical Properties

Molecular Formula C11H6F3NO4
Molecular Weight 273.16
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