Bragsin1(Bragsin 1)
Modify Date: 2025-09-21 06:30:50
Bragsin1(Bragsin 1) structure
|
Common Name | Bragsin1(Bragsin 1) | ||
|---|---|---|---|---|
| CAS Number | 369631-68-5 | Molecular Weight | 273.16 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H6F3NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bragsin1(Bragsin 1)Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1]. |
| Name | Bragsin1 |
|---|
| Description | Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 3 μM (BRAG2)[1] |
| References |
| Molecular Formula | C11H6F3NO4 |
|---|---|
| Molecular Weight | 273.16 |
| InChIKey | WEUSXIBCGCFOQR-UHFFFAOYSA-N |
| SMILES | Cc1ccc2oc(C(F)(F)F)cc(=O)c2c1[N+](=O)[O-] |