369631-68-5

369631-68-5 structure

Name: Bragsin1(Bragsin 1)
Chemical Name: Bragsin1
CAS Number: 369631-68-5
Molecular Formula: C₁₁H₆F₃NO₄
Molecular Weight: 273.16
Catalog: Research Areas Cancer
Create Date: 2019-03-30 17:26:34
Modify Date: 2024-01-14 21:04:05
Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].

Name	Bragsin1

Description	Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 3 μM (BRAG2)[1]
References	[1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.

Molecular Formula	C₁₁H₆F₃NO₄
Molecular Weight	273.16