Bragsin1(Bragsin 1)

Names

[ Name ]:
Bragsin1(Bragsin 1)

Biological Activity

[Description]:

Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 3 μM (BRAG2)[1]

[References]

[1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₆F₃NO₄

[ Molecular Weight ]:
273.16

Related Compounds

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