A-357300

Modify Date: 2025-09-01 09:50:05

A-357300 Structure
A-357300 structure
Common Name A-357300
CAS Number 369358-07-6 Molecular Weight 396.33200
Density N/A Boiling Point N/A
Molecular Formula C15H23Cl2N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of A-357300


A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM.

 Names

Name N'-[(2S,3R)-3-Amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl]-3-c hlorobenzohydrazide hydrochloride (1:1) (non-preferred name)

 Chemical & Physical Properties

Molecular Formula C15H23Cl2N3O3S
Molecular Weight 396.33200
Exact Mass 395.08400
PSA 136.73000
LogP 4.23830
InChIKey BYBVYIPUGPZRSX-OLZOCXBDSA-N
SMILES CC(C)SCCC(N)C(O)C(=O)NNC(=O)c1cccc(Cl)c1
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