Methyl Vinyl sulphone

Modify Date: 2024-01-02 05:06:26

Methyl Vinyl sulphone Structure
Methyl Vinyl sulphone structure
Common Name Methyl Vinyl sulphone
CAS Number 3680-02-2 Molecular Weight 90.144
Density 1.1±0.1 g/cm3 Boiling Point 201.2±13.0 °C at 760 mmHg
Molecular Formula C3H6OS Melting Point N/A
MSDS Chinese USA Flash Point 75.5±19.8 °C
Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger

 Names

Name Methyl vinyl sulfone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 201.2±13.0 °C at 760 mmHg
Molecular Formula C3H6OS
Molecular Weight 90.144
Flash Point 75.5±19.8 °C
Exact Mass 90.013931
PSA 42.52000
LogP -0.73
Vapour Pressure 0.4±0.4 mmHg at 25°C
Index of Refraction 1.505
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents. Irritant.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WR6825000
CHEMICAL NAME :
Sulfone, methyl vinyl
CAS REGISTRY NUMBER :
3680-02-2
BEILSTEIN REFERENCE NO. :
0878198
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C3-H6-O2-S
MOLECULAR WEIGHT :
106.15
WISWESSER LINE NOTATION :
WS1&1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
32 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 245,191,1990

 Safety Information

Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger
Hazard Statements H302-H310-H318
Precautionary Statements P280-P302 + P350-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T+:Verytoxic;
Risk Phrases R22;R27;R41
Safety Phrases S26-S28-S36/37/39-S45-S28A
RIDADR UN 2810 6.1/PG 1
WGK Germany 3
RTECS WR6825000
Packaging Group II
Hazard Class 6.1
HS Code 2904100000

 Synthetic Route

 Customs

HS Code 2904100000
Summary 2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles10

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Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway.

Oncotarget 5(14) , 5559-69, (2014)

Usp5 is a deubiquitinase (DUB) previously shown to regulate unanchored poly-ubiquitin (Ub) chains, p53 transcriptional activity and double-strand DNA repair. In BRAF mutant melanoma cells, Usp5 activi...

Protein reactions with methyl and ethyl vinyl sulfones.

J. Protein Chem. 7(1) , 49-54, (1988)

Disulfide bonds of bovine serum albumin and wool were reduced by n-tributylphosphine to sulfhydryl groups that were then modified by methyl or ethyl vinyl sulfone in a nucleophilic addition reaction t...

Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors.

Parasitol. Res. 95(1) , 73-6, (2005)

Previous studies have shown that proteasome inhibitors are novel agents for chemotherapy of human African trypanosomiasis or sleeping sickness. In this study, five peptide trileucine methyl vinyl sulf...

 Synonyms

1-methylsulfonylethene
EINECS 222-958-0
MFCD00007567
Ethene, (methylsulfinyl)-
(Methylsulfinyl)ethene
Methyl vinyl sulfoxide
Sulfoxide, methyl vinyl
Methyl Vinyl sulphone
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