Jatrorrhizine
Jatrorrhizine structure
|
Common Name | Jatrorrhizine | ||
|---|---|---|---|---|
| CAS Number | 3621-38-3 | Molecular Weight | 338.377 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20NO4+ | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of JatrorrhizineJatrorrhizine is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2]. |
| Name | 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol |
|---|---|
| Synonym | More Synonyms |
| Description | Jatrorrhizine is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2]. |
|---|---|
| Related Catalog | |
| Target |
Uptake-2 transporter[1] |
| In Vitro | Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters[1]. Jatrorrhizine significantly inhibits the plasma membrane monoamine transporter (PMAT) -mediated MPP+ uptake in a concentration-dependent manner with an IC50 value of 1.05 μM[1]. Jatrorrhizine demonstrates a more powerful inhibition on serotonin (5-HT) and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT[1]. Jatrorrhizine attenuates the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons[2]. |
| References |
| Molecular Formula | C20H20NO4+ |
|---|---|
| Molecular Weight | 338.377 |
| Exact Mass | 338.138672 |
| PSA | 51.80000 |
| LogP | -1.89 |
| InChIKey | MXTLAHSTUOXGQF-UHFFFAOYSA-O |
| SMILES | COc1cc2c(cc1O)CC[n+]1cc3c(OC)c(OC)ccc3cc1-2 |
| Storage condition | 2-8°C |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus.
J. Pharm. Pharmacol. 64(3) , 413-9, (2012) Postoperative ileus is major cause of postoperative complication and prolonged hospitalization. Jatrorrhizine, which is a protoberberine alkaloid isolated from the medicinal plants Berberis aristata a... |
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Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.
Xenobiotica 41(4) , 290-6, (2011) The absorption and transport mechanisms of berberine, palmatine, jateorhizine, and coptisine were studied using a Caco-2 cells uptake and transport model, with the addition of cyclosporin A and verapa... |
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Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate.
Biopharm. Drug Dispos. 33(3) , 135-45, (2012) Jatrorrhizine, a protoberberine alkaloid derived from Coptis chinensis, is currently under investigation as a natural gastric prokinetic drug candidate. In vitro and in vivo studies were conducted to ... |
| Neprotine |
| YATROIZINE HCL |
| Neprotin |
| Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy- |
| 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium |
| 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium |
| NEPROTINE IODIDE |
| Jateorrhizine |
| Jatrorrhizine |
| jatorrhizine |
| Jateorhizine |
| Jatrorrhizin |
| NEPROTINE HCL |
| 7,8,13,13a-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium |
| Yatrorizine |
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