药根碱结构式
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常用名 | 药根碱 | 英文名 | Jatrorrhizine |
|---|---|---|---|---|
| CAS号 | 3621-38-3 | 分子量 | 338.377 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C20H20NO4+ | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS09 |
信号词 | Warning |
药根碱用途Jatrorrhizine 是一种有效的口服活性 uptake-2 transporter 抑制剂,可以从各种中药植物中分离出来。 Jatrorrhizine 通过抑制 HT22 海马神经元中的 MAPK 途径,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用。 |
| 中文名 | 药根碱 |
|---|---|
| 英文名 | 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol |
| 中文别名 | 藥根鹼 |
| 英文别名 | 更多 |
| 描述 | Jatrorrhizine 是一种有效的口服活性 uptake-2 transporter 抑制剂,可以从各种中药植物中分离出来。 Jatrorrhizine 通过抑制 HT22 海马神经元中的 MAPK 途径,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用。 |
|---|---|
| 相关类别 | |
| 靶点 |
Uptake-2 transporter[1] |
| 体外研究 | 有机阳离子转运蛋白(OCTs)和质膜单胺转运蛋白(PMAT)是主要的摄取-2转运蛋白[1]。Jatrorhizine以浓度依赖性方式显着抑制质膜单胺转运蛋白(PMAT)介导的MPP+摄取,IC50值为1.05μM[1]。Jatrorhizine对hOCT2和hOCT3介导的5-羟色胺(5-HT)和去甲肾上腺素(NE)摄取的抑制作用比PMAT介导的更强[1]。Jatrorhizine减弱这些神经元中H2O2诱导的Bcl-2/Bax比值降低和caspase-3活化[2]。 |
| 参考文献 |
| 分子式 | C20H20NO4+ |
|---|---|
| 分子量 | 338.377 |
| 精确质量 | 338.138672 |
| PSA | 51.80000 |
| LogP | -1.89 |
| 储存条件 | 2-8°C |
| 海关编码 | 2933990090 |
|---|---|
| 中文概述 | 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus.
J. Pharm. Pharmacol. 64(3) , 413-9, (2012) Postoperative ileus is major cause of postoperative complication and prolonged hospitalization. Jatrorrhizine, which is a protoberberine alkaloid isolated from the medicinal plants Berberis aristata a... |
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Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.
Xenobiotica 41(4) , 290-6, (2011) The absorption and transport mechanisms of berberine, palmatine, jateorhizine, and coptisine were studied using a Caco-2 cells uptake and transport model, with the addition of cyclosporin A and verapa... |
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Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate.
Biopharm. Drug Dispos. 33(3) , 135-45, (2012) Jatrorrhizine, a protoberberine alkaloid derived from Coptis chinensis, is currently under investigation as a natural gastric prokinetic drug candidate. In vitro and in vivo studies were conducted to ... |
| Neprotine |
| YATROIZINE HCL |
| Neprotin |
| Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy- |
| 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium |
| 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium |
| NEPROTINE IODIDE |
| Jateorrhizine |
| Jatrorrhizine |
| jatorrhizine |
| Jateorhizine |
| Jatrorrhizin |
| NEPROTINE HCL |
| 7,8,13,13a-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium |
| Yatrorizine |
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