Diamfenetide

Modify Date: 2025-08-27 07:52:19

Diamfenetide structure	Common Name	Diamfenetide
	CAS Number	36141-82-9	Molecular Weight	372.41500
	Density	1.225g/cm3	Boiling Point	661.8ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₄N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	354.1ºC

Use of Diamfenetide

Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].

Name	N-[4-[2-[2-(4-acetamidophenoxy)ethoxy]ethoxy]phenyl]acetamide
Synonym	More Synonyms

Description	Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].
Related Catalog	Research Areas >> Infection
In Vitro	Diamfenetide (10-100 μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica[1]. Diamfenetide (100 μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes[2].
References	[1]. R S Rew, et al. Fasciola Hepatica: Effects of Diamfenetide Free Amine on in Vitro Physiology, Biochemistry, and Morphology. Exp Parasitol [2]. R S Rew, et al. Effects of Diamfenetide on Metabolic and Excretory Functions of Fasciola Hepatica in Vitro. Comp Biochem Physiol C

Density	1.225g/cm3
Boiling Point	661.8ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₅
Molecular Weight	372.41500
Flash Point	354.1ºC
Exact Mass	372.16900
PSA	85.89000
LogP	3.22380
Index of Refraction	1.595
InChIKey	JNEZCZPNQCQCFK-UHFFFAOYSA-N
SMILES	CC(=O)Nc1ccc(OCCOCCOc2ccc(NC(C)=O)cc2)cc1

Diamfenetide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC7042000

CHEMICAL NAME :: Acetamide, N,N'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-

CAS REGISTRY NUMBER :: 36141-82-9

BEILSTEIN REFERENCE NO. :: 2179741

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H24-N2-O5

MOLECULAR WEIGHT :: 372.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 3150 mg/kg

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 22(4),59,1988

HS Code	2924299090

Benzene, 1,1-[o...

CAS#:622-87-7

acetic acid

CAS#:64-19-7

~96%

Diamfenetide

CAS#:36141-82-9

Literature: Cablewski, Teresa; Gurr, Paul A.; Raner, Kevin D.; Strauss, Christopher R. Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5814 - 5817

Bis(2-bromoethy...

CAS#:5414-19-7

4-Acetamidophenol

CAS#:103-90-2

Diamfenetide

CAS#:36141-82-9

Literature: Chen et al. Yaoxue Xuebao, 1959 , vol. 7, p. 149,152 Chem.Abstr., 1960 , p. 5528

Precursor 4
CAS#:622-87-7 Benzene, 1,1-[o... CAS#:64-19-7 acetic acid CAS#:5414-19-7 Bis(2-bromoethy... CAS#:103-90-2 4-Acetamidophenol
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Diamfenetide

bis-[2-(4-acetylamino-phenoxy)-ethyl]-ether

diamphenethide

Coryphamin

Bis-[2-(4-acetylamino-phenoxy)-aethyl]-aether

N,N'-<Oxybis<2,1-(ethanediyloxy)-4,1-phenylene>>bisacetamide

Acemidophene

EINECS 252-886-5

Compound 68-198

Diamfenetidum [INN-Latin]

Diamfenetida [INN-Spanish]

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Diamfenetide
Price: Check
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Acetamide, N,N-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Email: enquiry@dycnchem.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Diamfenetide
Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/5g
Purity: 99.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

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Diamfenetide

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