Desglymidodrine
Modify Date: 2024-01-05 12:05:16
Desglymidodrine structure
|
Common Name | Desglymidodrine | ||
|---|---|---|---|---|
| CAS Number | 3600-87-1 | Molecular Weight | 197.23100 | |
| Density | N/A | Boiling Point | 364.3ºC at 760mmHg | |
| Molecular Formula | C10H15NO3 | Melting Point | 146-150ºC dec. | |
| MSDS | N/A | Flash Point | 174.1ºC | |
Use of DesglymidodrineDesglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2]. |
| Name | 2-Amino-1-(2,5-dimethoxyphenyl)ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Desglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2]. |
|---|---|
| Related Catalog | |
| Target |
α1A-adrenergic receptor:5.89 (pKi) α1B-adrenergic receptor:5.16 (pKi) rat alpha1D-adrenergic receptor:5.78 (pKi) human α2A-adrenoceptor:5.83 (pKi) |
| In Vitro | Desglymidodrine (ST 1059) (1-1000 μM) affects vein contraction with the pD2 values (negative logarithm of the concentration which causes 50% of the maximum possible effect) of 4.64 (- log mol/L) in dog isolated femoral veins and 4.48 (- log mol/L) in isolated human saphenous veins, respectively[1]. Desglymidodrine (ST 1059) acts on α1A, α1B, α1D in rat and α2A in human adrenoceptor with the pKi values of 5.89, 5.16, 5.78 and 5.83, respectively[2]. |
| References |
| Boiling Point | 364.3ºC at 760mmHg |
|---|---|
| Melting Point | 146-150ºC dec. |
| Molecular Formula | C10H15NO3 |
| Molecular Weight | 197.23100 |
| Flash Point | 174.1ºC |
| Exact Mass | 197.10500 |
| PSA | 64.71000 |
| LogP | 1.39620 |
| Index of Refraction | 1.542 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2922509090 |
CAS#:56979-58-9
CAS#:83436-65-1
CAS#:1204-21-3
CAS#:93-02-7![2-chloro-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide structure](https://www.chemsrc.com/caspic/131/60681-99-4.png)
CAS#:60681-99-4| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Midodrine Related Compound A |
| ST 1059 (Desglymidodrine) |
| 2-amino-1-(2,5-dimethoxyphenyl)ethan-1-ol |
| (+/-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol |
| 1-(2',5'-Dimethoxyphenyl)aminoethanol |
| 1-(2',5'-dimethoxyphenyl)-2-aminoethanol |
| de-glymidodrine |