3600-87-1

3600-87-1 structure

Name: Desglymidodrine
Chemical Name: 2-Amino-1-(2,5-dimethoxyphenyl)ethanol
CAS Number: 3600-87-1
Molecular Formula: C₁₀H₁₅NO₃
Molecular Weight: 197.23100
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-12-21 11:02:23
Modify Date: 2024-01-05 12:05:16
Desglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2].

Name	2-Amino-1-(2,5-dimethoxyphenyl)ethanol
Synonyms	Midodrine Related Compound A ST 1059 (Desglymidodrine) 2-amino-1-(2,5-dimethoxyphenyl)ethan-1-ol (+/-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol 1-(2',5'-Dimethoxyphenyl)aminoethanol 1-(2',5'-dimethoxyphenyl)-2-aminoethanol de-glymidodrine

Description	Desglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	α1A-adrenergic receptor:5.89 (pKi) α1B-adrenergic receptor:5.16 (pKi) rat alpha1D-adrenergic receptor:5.78 (pKi) human α2A-adrenoceptor:5.83 (pKi)
In Vitro	Desglymidodrine (ST 1059) (1-1000 μM) affects vein contraction with the pD2 values (negative logarithm of the concentration which causes 50% of the maximum possible effect) of 4.64 (- log mol/L) in dog isolated femoral veins and 4.48 (- log mol/L) in isolated human saphenous veins, respectively[1]. Desglymidodrine (ST 1059) acts on α1A, α1B, α1D in rat and α2A in human adrenoceptor with the pKi values of 5.89, 5.16, 5.78 and 5.83, respectively[2].
References	[1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20. [2]. Steven ABuckner, et al. ABT-866, a novel α1A-adrenoceptor agonist with antagonist properties at the α1B- and α1D-adrenoceptor subtypes,European Journal of Pharmacology,Volume 449, Issues 1–2,2002,Pages 159-1

Hazard Codes	Xn
RIDADR	NONH for all modes of transport
HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%