onjisaponin B

Modify Date: 2025-08-27 17:34:53

onjisaponin B Structure
onjisaponin B structure
Common Name onjisaponin B
CAS Number 35906-36-6 Molecular Weight 1573.671
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C75H112O35 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of onjisaponin B


Onjisaponin B is a natural product derived from Radix Polygalae. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease[1].

 Names

Name Senegin III
Synonym More Synonyms

 onjisaponin B Biological Activity

Description Onjisaponin B is a natural product derived from Radix Polygalae. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease[1].
Related Catalog
References

[1]. Wu AG, et al. Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells. Int J Mol Sci. 2013 Nov 15;14(11):22618-41.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C75H112O35
Molecular Weight 1573.671
Exact Mass 1572.698364
PSA 544.57000
LogP 1.78
Index of Refraction 1.656
InChIKey QSTBHNPMHXYCII-KJCIHCEPSA-N
SMILES COc1ccc(C=CC(=O)OC2C(C)OC(OC(=O)C34CCC(C)(C)CC3C3=CCC5C6(C)CC(O)C(OC7OC(CO)C(O)C(O)C7O)C(C)(C(=O)O)C6CCC5(C)C3(CO)CC4)C(OC3OC(C)C(OC4OCC(OC5OC(CO)C(O)C(O)C5O)C(O)C4O)C(O)C3O)C2OC2OC(C)C(O)C(O)C2O)cc1

 Synonyms

6-Deoxy-α-L-mannopyranosyl-(1->3)-[β-D-galactopyranosyl-(1->4)-β-D-xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)]-6-deoxy-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23,27
 -trihydroxy-23,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-β-D-galactopyranose
onjisaponin B
Onjisaponin-B
β-D-Galactopyranose, O-6-deoxy-α-L-mannopyranosyl-(1->3)-O-[O-β-D-galactopyranosyl-(1->4)-O-β-D-xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)]-6-deoxy-1-O-[(2β,3β)-3-(b
 η-D-glucopyranosyloxy)-2,23,27-trihydroxy-23,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-
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