35906-36-6

35906-36-6 structure

Name: onjisaponin B
Chemical Name: Senegin III
CAS Number: 35906-36-6
Molecular Formula: C₇₅H₁₁₂O₃₅
Molecular Weight: 1573.671
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-09-16 10:00:28
Modify Date: 2025-08-27 17:34:53
Onjisaponin B is a natural product derived from Radix Polygalae. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease[1].

Name	Senegin III
Synonyms	6-Deoxy-α-L-mannopyranosyl-(1->3)-[β-D-galactopyranosyl-(1->4)-β-D-xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)]-6-deoxy-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23,27 -trihydroxy-23,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-β-D-galactopyranose onjisaponin B Onjisaponin-B β-D-Galactopyranose, O-6-deoxy-α-L-mannopyranosyl-(1->3)-O-[O-β-D-galactopyranosyl-(1->4)-O-β-D-xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)]-6-deoxy-1-O-[(2β,3β)-3-(b η-D-glucopyranosyloxy)-2,23,27-trihydroxy-23,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-

Description	Onjisaponin B is a natural product derived from Radix Polygalae. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease[1].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease
References	[1]. Wu AG, et al. Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells. Int J Mol Sci. 2013 Nov 15;14(11):22618-41.