1,3,6,7-tetrahydroxyxanthone

Modify Date: 2024-01-02 09:48:30

1,3,6,7-tetrahydroxyxanthone Structure
1,3,6,7-tetrahydroxyxanthone structure
 Common Name 1,3,6,7-tetrahydroxyxanthone
CAS Number 3542-72-1 Molecular Weight 260.20
Density 1.8±0.1 g/cm3 Boiling Point 595.1±50.0 °C at 760 mmHg
Molecular Formula C13H8O6 Melting Point N/A
MSDS N/A Flash Point 237.8±23.6 °C

 Use of 1,3,6,7-tetrahydroxyxanthone


Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

 Names

Name norathyriol
Synonym More Synonyms

 1,3,6,7-tetrahydroxyxanthone Biological Activity

Description Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
Related Catalog
Target

PPARα:92.8 μM (IC50)

PPARβ:102.4 μM (IC50)

PPARγ:153.5 μM (IC50)
In Vitro Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3]. Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3]Cell Growth Assay WB Cell Viability Assay[3] Cell Line: Mouse skin epidermal JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 24 or 72 hours Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death. Western Blot Analysis[3] Cell Line: JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 2 hours Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.
In Vivo Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1]. Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4]. Animal Model: Adult Kunming mice weighing 18-22 g[4] Dosage: 0.92, 1.85 and 3.7 mg/kg Administration: Administered intragastrically; twice daily for five times Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.
References

[1]. Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015.

[2]. Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42.

[3]. Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70.

[4]. Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 595.1±50.0 °C at 760 mmHg
Molecular Formula C13H8O6
Molecular Weight 260.20
Flash Point 237.8±23.6 °C
Exact Mass 260.032074
PSA 111.13000
LogP 0.95
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.801

 Safety Information

Hazard Codes Xi
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Norathyriol
magniferitin
1,3,6,7-Tetrahydroxyxanthen-9-one
1,3,6,7-Tetrahydroxyxantone
1,3,6,7-tetrahydroxyxanthone
2,4,6,7-Tetrahydroxyxanthone
1,3,6,7-Tetrahydroxy-9H-xanthen-9-one
9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: Norathyriol
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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