(2E)-3-(2-hydroxyphenyl)prop-2-enal

Modify Date: 2024-01-05 18:38:32

(2E)-3-(2-hydroxyphenyl)prop-2-enal structure	Common Name	(2E)-3-(2-hydroxyphenyl)prop-2-enal
	CAS Number	3541-42-2	Molecular Weight	148.16
	Density	1.2±0.1 g/cm3	Boiling Point	311.3±17.0 °C at 760 mmHg
	Molecular Formula	C₉H₈O₂	Melting Point	126ºC
	MSDS	USA	Flash Point	131.8±13.5 °C

Use of (2E)-3-(2-hydroxyphenyl)prop-2-enal

2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3].

Name	2-hydroxycinnamaldehyde
Synonym	More Synonyms

Description	2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology
References	[1]. Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84. [2]. Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55. [3]. Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884.

Description

Related Catalog

Signaling Pathways >> Stem Cell/Wnt >> STAT

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Stem Cell/Wnt >> Wnt

Signaling Pathways >> JAK/STAT Signaling >> STAT

Research Areas >> Inflammation/Immunology

References

[1]. Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84.

[2]. Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55.

[3]. Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884.

Density	1.2±0.1 g/cm3
Boiling Point	311.3±17.0 °C at 760 mmHg
Melting Point	126ºC
Molecular Formula	C₉H₈O₂
Molecular Weight	148.16
Flash Point	131.8±13.5 °C
Exact Mass	148.052429
PSA	37.30000
LogP	2.14
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.618

(2E)-3-(2-hydroxyphenyl)prop-2-enal MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD6565000

CHEMICAL NAME :: Cinnamaldehyde, o-hydroxy-

CAS REGISTRY NUMBER :: 3541-42-2

LAST UPDATED :: 199209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H8-O2

MOLECULAR WEIGHT :: 148.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 19,191,1985

Hazard Codes	Xn
HS Code	2912499000

HS Code	2912499000
Summary	2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

(2E)-3-(2-Hydroxyphenyl)acrylaldehyde

Hydroxycinnamaldehyde

o-hydroxycinnamaldehyde

(2E)-3-(2-hydroxyphenyl)prop-2-enal

2'-hydroxycinnamaldehyde

3-(2-Hydroxyphenyl)acrylaldehyde

2-Propenal, 3-(2-hydroxyphenyl)-, (2E)-

2-Hydroxy-zimtaldehyd

2-hydroxycinnamicaldehyde

o-hydroxy-cinnamaldehyd

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Propenal,3-(2-hydroxyphenyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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