Fosravuconazole

Modify Date: 2025-08-25 10:49:04

Use of Fosravuconazole

Fosravuconazole is a prodrug of ravuconazole, with antifungal activity.

Name	[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1,2,4-triazol-1-yl)butan-2-yl]oxymethyl dihydrogen phosphate
Synonym	More Synonyms

Description	Fosravuconazole is a prodrug of ravuconazole, with antifungal activity.
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection
Target	Fungal[1]
In Vitro	Fosravuconazole (BMS-379224) is a prodrug of ravuconazole, with antifungal activity[1].
In Vivo	Fosravuconazole (BMS-379224) is rapidly conversed to ravuconazole upon iv administration to rats. Fosravuconazole shows comparable efficacy at inhibiting C. albicans infection model in mice as orally administered ravuconazole[1].
References	[1]. Ueda Y, et al. Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3669-72.

Molecular Formula	C₂₃H₂₀F₂N₅O₅PS
Molecular Weight	547.47100
Exact Mass	547.08900
PSA	181.43000
LogP	4.33408
InChIKey	SYTNEMZCCLUTNX-NPMXOYFQSA-N
SMILES	CC(c1nc(-c2ccc(C#N)cc2)cs1)C(Cn1cncn1)(OCOP(=O)(O)O)c1ccc(F)cc1F

Benzonitrile,4-(2-((1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-((phosphonooxy)methoxy)-3-(1H-1,2,4-triazol-1-yl)propyl)-4-thiazolyl)

UNII-L4Q6O5430L

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