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Fosravuconazole

Names

[ CAS No. ]:
351227-64-0

[ Name ]:
Fosravuconazole

[Synonym ]:
Benzonitrile,4-(2-((1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-((phosphonooxy)methoxy)-3-(1H-1,2,4-triazol-1-yl)propyl)-4-thiazolyl)
UNII-L4Q6O5430L

Biological Activity

[Description]:

Fosravuconazole is a prodrug of ravuconazole, with antifungal activity.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Infection

[Target]

Fungal[1]


[In Vitro]

Fosravuconazole (BMS-379224) is a prodrug of ravuconazole, with antifungal activity[1].

[In Vivo]

Fosravuconazole (BMS-379224) is rapidly conversed to ravuconazole upon iv administration to rats. Fosravuconazole shows comparable efficacy at inhibiting C. albicans infection model in mice as orally administered ravuconazole[1].

[References]

[1]. Ueda Y, et al. Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3669-72.


[Related Small Molecules]

Cycloheximide | Hygromycin B | Cancidas | 5-Flucytosine | Posaconazole | Terbinafine | Ciclopirox | Isavuconazole | Anidulafungin | Clotrimazole | Clioquinol | Miconazole Nitrate | Pimaricin | Ascomycin | Econazole (nitrate)

Chemical & Physical Properties

[ Molecular Formula ]:
C23H20F2N5O5PS

[ Molecular Weight ]:
547.47100

[ Exact Mass ]:
547.08900

[ PSA ]:
181.43000

[ LogP ]:
4.33408

Related Compounds

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