351227-64-0

351227-64-0 structure

Name: Fosravuconazole
Chemical Name: [(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1,2,4-triazol-1-yl)butan-2-yl]oxymethyl dihydrogen phosphate
CAS Number: 351227-64-0
Molecular Formula: C₂₃H₂₀F₂N₅O₅PS
Molecular Weight: 547.47100
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2017-09-06 04:40:45
Modify Date: 2025-08-25 10:49:04
Fosravuconazole is a prodrug of ravuconazole, with antifungal activity.

Name	[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1,2,4-triazol-1-yl)butan-2-yl]oxymethyl dihydrogen phosphate
Synonyms	Benzonitrile,4-(2-((1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-((phosphonooxy)methoxy)-3-(1H-1,2,4-triazol-1-yl)propyl)-4-thiazolyl) UNII-L4Q6O5430L

Description	Fosravuconazole is a prodrug of ravuconazole, with antifungal activity.
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection
Target	Fungal[1]
In Vitro	Fosravuconazole (BMS-379224) is a prodrug of ravuconazole, with antifungal activity[1].
In Vivo	Fosravuconazole (BMS-379224) is rapidly conversed to ravuconazole upon iv administration to rats. Fosravuconazole shows comparable efficacy at inhibiting C. albicans infection model in mice as orally administered ravuconazole[1].
References	[1]. Ueda Y, et al. Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3669-72.