4′-Demethylnobiletin
Modify Date: 2025-08-25 18:20:52
4′-Demethylnobiletin structure
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Common Name | 4′-Demethylnobiletin | ||
|---|---|---|---|---|
| CAS Number | 34810-62-3 | Molecular Weight | 388.36800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 4′-Demethylnobiletin4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling[1]. |
| Name | 4'-demethylnobiletin |
|---|---|
| Synonym | More Synonyms |
| Description | 4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 4′-Demethylnobiletin(1-100 μM, 0-60 min) 可以以时间和浓度依赖性的方式激活大鼠海马神经元中 ERK 和 CREB 的磷酸化，并以 PKA/MEK/ERK 途径依赖的方式，同时也可以通过激活 PKA/MEK/ERK 依赖信号通路刺激 CRE 介导的转录[1]。 |
| In Vivo | 4′-Demethylnobiletin (10 or 50 mg/kg, ip, once daily for seven consecutive days)在雄性 ddY 小鼠中可以剂量依赖性地逆转了 MK-801 诱导的学习障碍，而不影响小鼠的活动能力。其中用 MK-801 处理的小鼠比对照组小鼠表现出更少的冻结，并诱导小鼠的海马体中的 ERK 学习激活抑制，而 4′-Demethylnobiletin 也可以逆转该行为[1]。 4′-Demethylnobiletin (10 or 50 mg/kg, ip, once daily for seven consecutive days)可以逆转 MK-801 对海马神经元中 NMDA 刺激的 ERK 和 PKA 底物磷酸化的抑制[1]。 |
| References |
| Molecular Formula | C20H20O8 |
|---|---|
| Molecular Weight | 388.36800 |
| Exact Mass | 388.11600 |
| PSA | 96.59000 |
| LogP | 3.20860 |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:478-01-3
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