(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide

Modify Date: 2024-01-20 08:45:34

(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide Structure
(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide structure
Common Name (D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
CAS Number 340821-13-8 Molecular Weight 1046.26000
Density N/A Boiling Point N/A
Molecular Formula C50H67N11O10S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide


(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with Kds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively[1].

 Names

Name (D-Phe5,Cys6·11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
Synonym More Synonyms

  Biological Activity

Description (D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with Kds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively[1].
Related Catalog
Target

Kd: 0.61 nM (SSTR5), 11.05 nM (SSTR3), 23.5 nM (SSTR2), 1200 nM (SSTR1), >1000 nM (SSTR4)[1]

References

[1]. Nikiforovich GV, et al. Molecular modeling suggests conformational scaffolds specifically targeting five subtypes of somatostatin receptors. Chem Biol Drug Des. 2007 Mar;69(3):163-9.  

 Chemical & Physical Properties

Molecular Formula C50H67N11O10S2
Molecular Weight 1046.26000
Exact Mass 1045.45000
PSA 396.89000
LogP 3.16560

 Synonyms

(D-PHE5,CYS6,11,N-ME-D-TRP8)-SOMATOSTATIN-14 (5-12) AMIDE
H-D-PHE-CYS-PHE-N-ME-D-TRP-LYS-THR-CYS-THR-NH2
(D-Phe5,Cys6
(N-Me-D-Trp4,Thr8)-Octreotide aMide,(N-Me-D-Trp4)-Octreotate aMide
H-D-Phe-Cys-Phe-N-Me-D-Trp-Lys-Thr-Cys-Thr-NH2,(Disulfide bond)