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(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide

Names

[ CAS No. ]:
340821-13-8

[ Name ]:
(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide

[Synonym ]:
(D-PHE5,CYS6,11,N-ME-D-TRP8)-SOMATOSTATIN-14 (5-12) AMIDE
H-D-PHE-CYS-PHE-N-ME-D-TRP-LYS-THR-CYS-THR-NH2
(D-Phe5,Cys6
(N-Me-D-Trp4,Thr8)-Octreotide aMide,(N-Me-D-Trp4)-Octreotate aMide
H-D-Phe-Cys-Phe-N-Me-D-Trp-Lys-Thr-Cys-Thr-NH2,(Disulfide bond)

Biological Activity

[Description]:

(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with Kds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor
Research Areas >> Neurological Disease

[Target]

Kd: 0.61 nM (SSTR5), 11.05 nM (SSTR3), 23.5 nM (SSTR2), 1200 nM (SSTR1), >1000 nM (SSTR4)[1]


[References]

[1]. Nikiforovich GV, et al. Molecular modeling suggests conformational scaffolds specifically targeting five subtypes of somatostatin receptors. Chem Biol Drug Des. 2007 Mar;69(3):163-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C50H67N11O10S2

[ Molecular Weight ]:
1046.26000

[ Exact Mass ]:
1045.45000

[ PSA ]:
396.89000

[ LogP ]:
3.16560

Related Compounds