Oxaceprol

Modify Date: 2025-08-27 18:01:59

Oxaceprol Structure
Oxaceprol structure
 Common Name Oxaceprol
CAS Number 33996-33-7 Molecular Weight 173.167
Density 1.4±0.1 g/cm3 Boiling Point 442.1±45.0 °C at 760 mmHg
Molecular Formula C7H11NO4 Melting Point 132-133 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 221.2±28.7 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of Oxaceprol


Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis. Oxaceprol markedly inhibited inflammatory cell infiltration and bone damage in the adjuvant-injected paw. oxaceprol was effective at inhibiting periarticular soft tissue inflammation.[1] IV Injection: 50mg/kg.[2]

 Names

Name Oxaceprol
Synonym More Synonyms

 Oxaceprol Biological Activity

Description Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis. Oxaceprol markedly inhibited inflammatory cell infiltration and bone damage in the adjuvant-injected paw. oxaceprol was effective at inhibiting periarticular soft tissue inflammation.[1] IV Injection: 50mg/kg.[2]
Related Catalog
References

[1]. Ionac M et al. Oxaceprol, an atypical inhibitor of inflammation and joint damage. Pharmacol Res, 1996 Jun, 33(6):367-73.

[2]. Harris A et al. Effects of oxaceprol on the microcirculation in ischemia/reperfusion injury. Eur J Med Res, 1998 Apr 8, 3(4):182-8.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 442.1±45.0 °C at 760 mmHg
Melting Point 132-133 °C (dec.)(lit.)
Molecular Formula C7H11NO4
Molecular Weight 173.167
Flash Point 221.2±28.7 °C
Exact Mass 173.068802
PSA 77.84000
LogP -2.04
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.561
InChIKey BAPRUDZDYCKSOQ-RITPCOANSA-N
SMILES CC(=O)N1CC(O)CC1C(=O)O

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R41
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

 Synthetic Route

Ethyl allylmalonate structure

Ethyl allylmalonate

CAS#:2049-80-1

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
N/A structure

N/A

CAS#:2584-72-7

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
3-bromo-5-chloromethyl-dihydro-furan-2-one structure

3-bromo-5-chlor...

CAS#:854657-58-2

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
5-bromomethyl-3-chloro-dihydro-furan-2-one structure

5-bromomethyl-3...

CAS#:857479-57-3

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
N/A structure

N/A

CAS#:5281-69-6

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
allylmalonic acid structure

allylmalonic acid

CAS#:2583-25-7

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
N/A structure

N/A

CAS#:408539-58-2

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
ethyl 5-[(1,3-dioxoisoindol-2-yl)methyl]-2-oxo-oxolane-3-carboxylate structure

ethyl 5-[(1,3-d...

CAS#:6284-28-2

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141
Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7

D-Proline, 4-hydroxy-,(4R)-rel- structure

D-Proline, 4-hy...

CAS#:49761-17-3

~%

Oxaceprol Structure

Oxaceprol

CAS#:33996-33-7

Literature: Journal of the American Chemical Society, , vol. 76, p. 139,141

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles25

More Articles
Oxaceprol, an atypical inhibitor of inflammation, reduces leukocyte adherence in mouse antigen-induced arthritis.

Acta Orthop. Scand. 72(3) , 293-8, (2001)

Oxaceprol (N-acetyl-L-hydroxyproline), an atypical inhibitor of inflammation, is an established drug forjoint disease without serious side-effects. Recent studies have emphasized that oxaceprol has an...

Determination of oxaceprol in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.

J. Pharm. Biomed. Anal. 54(1) , 173-8, (2011)

A sensitive method for the quantification of oxaceprol in rat plasma using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. Sample pretreatment involved a simp...

[Assessment of the placebo effect of symptomatic slow-acting anti-arthritics].

Presse Med. 27(5) , 211-4, (1998)

Assess the importance of the mid-term placebo effect of symptomatic slow acting drugs given for osteoarthritis.We analyzed six controlled trials available in the literature. Trial duration ranged from...

 Synonyms

AHP-200
trans-1-Acetyl-4-hydroxy-1-proline
Jonctum
(2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
N-Acetyl-L-hydroxyproline
Oxaceprol
L-Proline, 1-acetyl-4-hydroxy-, (4R)-
(2S,4R)-N-acetyl-4-hydroxyproline
CO-61
trans-l-prolin
(4R)-1-Acetyl-4-hydroxy-L-proline
(2S,4R)-1-acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid
MFCD00037339
(-)-1-Acetyl-4-hydroxy-L-proline
AC-HYDROXYPROLINE
Hyp4001Ac-Hyp-Oh
N-acetyl-trans-4-hydroxy-L-proline
EINECS 251-780-6
(2S,4R)-1-acetyl-4-hydroxy-proline
1-acetyl-trans-4-hydroxy-L-proline
N-AC-L-HYP
Ac-L-Hyp-OH
AC-HYP-OH
N-Acetyl-L-4-Hydroxyproline
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