Hypophyllanthin
Modify Date: 2025-08-21 17:38:40
Hypophyllanthin structure
|
Common Name | Hypophyllanthin | ||
|---|---|---|---|---|
| CAS Number | 33676-00-5 | Molecular Weight | 430.491 | |
| Density | 1.158 | Boiling Point | 511.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H30O7 | Melting Point | 129-130℃ | |
| MSDS | N/A | Flash Point | 200.8±30.0 °C | |
Use of HypophyllanthinHypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. |
| Name | (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole |
|---|---|
| Synonym | More Synonyms |
| Description | Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
P-gp[2] |
| In Vitro | Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1]. |
| References |
| Density | 1.158 |
|---|---|
| Boiling Point | 511.1±50.0 °C at 760 mmHg |
| Melting Point | 129-130℃ |
| Molecular Formula | C24H30O7 |
| Molecular Weight | 430.491 |
| Flash Point | 200.8±30.0 °C |
| Exact Mass | 430.199158 |
| PSA | 64.61000 |
| LogP | 3.77 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | LBJCUHLNHSKZBW-XGHQBKJUSA-N |
| SMILES | COCC1Cc2cc(OC)c3c(c2C(c2ccc(OC)c(OC)c2)C1COC)OCO3 |
|
~%
Hypophyllanthin CAS#:33676-00-5 |
| Literature: Schneiders, Gail E.; Stevenson, Robert Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 999 - 1004 |
|
~%
Hypophyllanthin CAS#:33676-00-5 |
| Literature: Tetrahedron Letters, , vol. 22, p. 393 - 396 |
![(6aR,9aR,10S)-5-bromo-10-(3,4-dimethoxyphenyl)-4-methoxy-6a,7,9a,10-tetrahydrofuro[3',4':6,7]naphtho[1,2-d][1,3]dioxol-9(6H)-one structure](https://image.chemsrc.com/caspic/383/78246-77-2.png)
| (7R,8R,9S)-9-(3,4-Dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxole |
| UNII:22ZZ21E33P |
| Naphtho[1,2-d]-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7R,8R,9S)- |
| Hypophyllanthin |
| Hypophyllantin |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Hypophyllanthin
- Price: Check
- Purity: 95.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Hypophyllanthin
- Price: ￥4000.0/5mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Hypophyllanthin
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: (7S,8S,9R)-9-(3,4-Dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)naphtho[1,2-d]-1,3-dioxole
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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