SW157765
Modify Date: 2025-11-30 11:54:52
SW157765 structure
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Common Name | SW157765 | ||
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| CAS Number | 332063-87-3 | Molecular Weight | 331.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H13N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SW157765SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2]. |
| Name | SW157765 |
|---|
| Description | SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2]. |
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| Related Catalog | |
| In Vitro | SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1]. |
| References |
| Molecular Formula | C19H13N3O3 |
|---|---|
| Molecular Weight | 331.32 |
| InChIKey | QSSYRORXXFTVFI-GQCTYLIASA-N |
| SMILES | O=C(C=Cc1ccco1)Nc1ccc2oc(-c3ccncc3)nc2c1 |