SW157765

Names

[ CAS No. ]:
332063-87-3

[ Name ]:
SW157765

Biological Activity

[Description]:

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].

[References]

[1]. Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269.

[2]. McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₃N₃O₃

[ Molecular Weight ]:
331.32

Related Compounds

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