332063-87-3

332063-87-3 structure

Name: SW157765
Chemical Name: SW157765
CAS Number: 332063-87-3
Molecular Formula: C₁₉H₁₃N₃O₃
Molecular Weight: 331.32
Catalog: Research Areas Cancer
Create Date: 2021-10-19 18:45:57
Modify Date: 2022-01-24 17:55:53
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].

Name	SW157765

Description	SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].
Related Catalog	Research Areas >> Cancer
In Vitro	SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].
References	[1]. Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269. [2]. McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29.

Molecular Formula	C₁₉H₁₃N₃O₃
Molecular Weight	331.32