IMR-1A
Modify Date: 2024-01-03 23:12:24
IMR-1A structure
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Common Name | IMR-1A | ||
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| CAS Number | 331862-41-0 | Molecular Weight | 325.360 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C13H11NO5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IMR-1AIMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish. |
| Name | [2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid |
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| Synonym | More Synonyms |
| Description | IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C13H11NO5S2 |
| Molecular Weight | 325.360 |
| Exact Mass | 325.007874 |
| LogP | 0.78 |
| Appearance of Characters | yellow solid |
| Index of Refraction | 1.699 |
| Storage condition | -20℃ |
| acetic acid, 2-[4-[(E)-(2-mercapto-4-oxo-5(4H)-thiazolylidene)methyl]-2-methoxyphenoxy]- |
| Acetic acid, 2-[2-methoxy-4-[(E)-(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]- |
| {2-Methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid |
| [2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid |
| MFCD08681051 |
| IMR-1A |