IMR-1
Modify Date: 2024-01-10 10:08:20
IMR-1 structure
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Common Name | IMR-1 | ||
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| CAS Number | 310456-65-6 | Molecular Weight | 353.413 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H15NO5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IMR-1IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO). In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish. |
| Name | Ethyl {2-methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate |
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| Synonym | More Synonyms |
| Description | IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO). In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C15H15NO5S2 |
| Molecular Weight | 353.413 |
| Exact Mass | 353.039154 |
| LogP | 1.38 |
| Appearance of Characters | yellow solid |
| Index of Refraction | 1.641 |
| Storage condition | -20℃ |
| Ethyl {2-methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate |
| Acetic acid, 2-[2-methoxy-4-[(E)-(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester |
| IMR-1 |