331862-41-0

331862-41-0 structure

Name: IMR-1A
Chemical Name: [2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid
CAS Number: 331862-41-0
Molecular Formula: C₁₃H₁₁NO₅S₂
Molecular Weight: 325.360
Catalog: Signaling Pathways Stem Cell/Wnt Notch
Create Date: 2018-02-03 16:01:05
Modify Date: 2024-01-03 23:12:24
IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.

Name	[2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid
Synonyms	acetic acid, 2-[4-[(E)-(2-mercapto-4-oxo-5(4H)-thiazolylidene)methyl]-2-methoxyphenoxy]- Acetic acid, 2-[2-methoxy-4-[(E)-(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]- {2-Methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid [2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid MFCD08681051 IMR-1A

Description	IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Notch Research Areas >> Cancer
References	[1]. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.