MK 0557

Modify Date: 2025-08-25 21:46:55

MK 0557 structure	Common Name	MK 0557
	CAS Number	328232-95-7	Molecular Weight	406.41000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₉FN₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK 0557

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.

Name	N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
Synonym	More Synonyms

Description	MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor Research Areas >> Metabolic Disease
Target	Ki: 1.6 nM (Y5)[1]
In Vitro	MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet (4.2 kcal/g) and treated with MK-0557 at 30 mg/kg PO QD, MK-0557 causes a 40% reduction inbody-weight gain at day 35[2].
References	[1]. Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2738-43. [2]. Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4(4):275-82.

Molecular Formula	C₂₂H₁₉FN₄O₃
Molecular Weight	406.41000
Exact Mass	406.14400
PSA	89.34000
LogP	3.02290
Storage condition	2-8℃

1'-OXO-SPIRO[CY...

CAS#:569351-62-8

MK 0557

CAS#:328232-95-7

Literature: Iida, Takehiko; Satoh, Hiroki; Maeda, Kenji; Yamamoto, Yuhei; Asakawa, Ken-Ichi; Sawada, Naotaka; Wada, Toshihiro; Kadowaki, Chie; Itoh, Takahiro; Mase, Toshiaki; Weissman, Steven A.; Tschaen, Dave; Krska, Shane; Volante Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9222 - 9229

tert-butyl (1r,...

CAS#:870466-68-5

MK 0557

CAS#:328232-95-7

N-Phenylisonico...

CAS#:3034-31-9

MK 0557

CAS#:328232-95-7

Ethyl 4-oxocycl...

CAS#:17159-79-4

MK 0557

CAS#:328232-95-7

N/A

CAS#:923984-29-6

MK 0557

CAS#:328232-95-7

Literature: MERCK and CO., INC.; BANYU PHARMACEUTICAL CO., LTD. Patent: WO2007/16028 A2, 2007 ; Location in patent: Page/Page column 13; 14 ; WO 2007/016028 A2

3-amino-1-(2-fl...

CAS#:685094-07-9

TRANS-1'-OXO-SP...

CAS#:328233-23-4

~17%

MK 0557

CAS#:328232-95-7

Literature: Haga, Yuji; Sakamoto, Toshihiro; Shibata, Takunobu; Nonoshita, Katsumasa; Ishikawa, Makoto; Suga, Takuya; Takahashi, Hirobumi; Takahashi, Toshiyuki; Takahashi, Hidekazu; Ando, Makoto; Murai, Takashi; Gomori, Akira; Oda, Zenjun; Kitazawa, Hidefumi; Mitobe, Yuko; Kanesaka, Maki; Ohe, Tomoyuki; Iwaasa, Hisashi; Ishii, Yasuyuki; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 19 p. 6971 - 6982

Precursor 6
CAS#:569351-62-8 1'-OXO-SPIRO[CY... CAS#:870466-68-5 tert-butyl (1r,... CAS#:3034-31-9 N-Phenylisonico... CAS#:17159-79-4 Ethyl 4-oxocycl...
CAS#:685094-07-9 3-amino-1-(2-fl... CAS#:328233-23-4 TRANS-1'-OXO-SP...
DownStream 0

UNII-HVE36P8422

MK-0557

1'-cyclohexane]-4'-carboxamide

MK 0557

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MK-0557
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: MK-0557
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: MK-0557
Price: $600.0/100mg $1100.0/250mg $2200.0/1g $220.0/10ml
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: $185/10mM*1mLinDMSO

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MK 0557

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.